Systems Pharmacology is truly a multidisciplinary paradigm. This approach of drug discovery and development is based on integration of clinical, pharmacological and physiological facts. By utilizing this paradigm, the decision-making process during the development of novel drug targets is enhanced. Our systems pharmacology-based tools can enable the decision-making process by providing the quantitative answers to critical questions in the development of novel pharmacological concepts such as: what dosing regime is required? What are the safety and efficacy profiles for the best in class and first in class drug?; response variation of different sub-population of patients new pharmacological entities ?